Serial coms go straight to the main microcontroller itself. Assuming that one is not damaged (otherwise game over), I suggest the following:
Scope the 3.3V line to make sure the regulator is still working properly. Badly regulated 3.3V could cause such issues
Scope the serial lines to see if anything happens at all (and if so, what). Especially during startup Nextion should transmit some default values (as defined in the Nextion Instruction Set).
Kind regards,
Max
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